Cole and Delsin can use their parkour skills to jump and climb buildings throughout the city, along with their powers to help them fight enemies. The player freely roams around the city, while fighting crime or creating havoc along the way.

In the first two games, the player controls Cole MacGrath in the third game, the player controls Delsin Rowe in the standalone expansion First Light, they control Fetch. It features American government agencies such as the FBI, NSA and DARPA, along with agencies fabricated for the series, such as the DUP (Department of Unified Protection), an agency with the sole purpose of stopping conduits, now labeled 'bio-terrorists', from causing mass destruction similar to what was caused by Cole MacGrath. is occasionally mentioned, and Infamous Second Son takes place in Seattle. The series takes place in the present-day United States with real and alternate versions of real cities, such as the setting of Infamous, Empire City, which resembles New York City and the setting of Infamous 2, New Marais, which resembles New Orleans ( Infamous: Festival of Blood also takes place in this city). A comic book series of the same name was published by DC Comics. The series consists of three main games: Infamous, Infamous 2 and Infamous Second Son, alongside expansion titles Infamous: Festival of Blood and Infamous First Light. The series follows the adventures of Cole MacGrath, Delsin Rowe and Abigail 'Fetch' Walker, super-powered 'Conduits' who must decide their own destinies of becoming either good or evil. Infamous (stylized as inFAMOUS) is a series of action-adventure platform games developed by Sucker Punch Productions and published by Sony Computer Entertainment for PlayStation 3 and PlayStation 4.

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